Missouri has a ton of positives for budding entrepreneurs looking to open a new business. The state boasts a high business success rate and high startup density, coupled with a low cost of living. 2013 US census data found that Missouri led the nation in the creation of new businesses, with a rate of 16%.

Kansas City tops the list of cities in which to start a business in the Show Me State. Home to a large Ford Motor Company manufacturing plant, the Sanofi-Aventis plant, one of the largest drug manufacturing plants in the country, Dairy Farmers of America, the largest dairy co-op in the nation and a large federal government sector maintaining 30,000 jobs, the city has a bustling and diverse economy.

In recent years, numerous accelerators and organizations devoted to nurturing Kansas City’s fledgling startup ecosystem have opened, including Kansas City Startup Village, providing a large support network for young entrepreneurs.

The presence of over a dozen universities in the metropolitan area providing a skilled, young employee pool is even greater incentive for starting a business in the city.

MOKansas CityPlatte
MOBlue SpringsJackson

Only cities with over 50,000 inhabitants are reported in the results. Some data had to be interpolated to the county level and extrapolated to all the cities in the county. We concentrated on the following metrics to obtain our ranking: Cost of livingBest state for businessUnemploymentKauffman index, and Universities.


I'm an entrepreneur myself. When talking to others who want to start their own business, they often get wrapped up in the nitty gritty of paperwork and forming the company. They forget that what really matters is customers, sales, and profit. That's why I created How to Start an a simple resource and guide so you can spend less time on forming your company, and more time on building it.

My lawyers want me to remind you that I'm not a lawyer and that I'm completely unqualified to offer legal advice. This site is meant to serve as a reference for you on your journey. If you have questions or concerns, please contact a qualified lawyer (or accountant) to help you. Also, as a general rule, never take random legal advice on the internet.