Best Cities to Start a Business in Mississippi

Last updated: March 19th, 2024

The conditions for starting a business in Mississippi are quickly improving, making it a good choice for an entrepreneur looking for a destination off the beaten path. Mississippi’s cost of living is the lowest in the United States, which is certainly a help in the early stages of growing a business.

Jackson, the state’s capital and largest city, is the best place to start a business in Mississippi. The city’s downtown area has witnessed the recent emergence of the coworking spaces Coalesce and Mantle. These coworking spaces are dedicated to providing cheap office space to entrepreneurs in the tech fields and others while also offering guidance and the opportunity to collaborate with like-minded people.

Innovate Mississippi is an organization in Jackson that uses a more hands-on approach to assisting young businesses. It assesses your business’s risk and potential and can help to link you with much-needed investment capital.

Jackson has other positives for emerging companies, including widely available high-speed fiber internet.


Only cities with over 50,000 inhabitants are reported in the results. Some data had to be interpolated to the county level and extrapolated to all the cities in the county. We concentrated on the following metrics to obtain our ranking: Cost of livingBest state for businessUnemploymentKauffman index, and Universities.

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